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Metabolism Alprazolam is extensively metabolized in humans, mostly by cytochrome P450 3A4 (CYP3A4), to 2 major active metabolites inside the plasma: four-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation amounts of the two active metabolites are a lot less than four% on the mum or dad. The reported relative potencies in benzodiazep